Seven-Coordinate CoII, FeII and Six-Coordinate NiII Amide-Appended Macrocyclic Complexes as ParaCEST Agents in Biological Media

Seven-Coordinate CoII, FeII and Six-Coordinate NiII Amide-Appended Macrocyclic Complexes as ParaCEST Agents in Biological Media

The solution chemistry and solid-state structures of the Co(II), Fe(II), and Ni(II) complexes of 7,13-bis(carbamoylmethyl)-1,4,10-trioxa-7,13-diazacyclopentadecane (L) are reported as members of a new class of paramagnetic chemical exchange saturation transfer (paraCEST) MRI contrast agents that contain transition metal ions. Crystallographic data show that nitrogen and oxygen donor atoms of th...

CoCEST: cobalt(II) amide-appended paraCEST MRI contrast agents.

The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging.

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters...

Bonding in Low-Coordinate Complexes

The binding assessment with human serum albumin of novel six-coordinate Pt(IV) complexes, containing bidentate nitrogen donor/methyl ligands

The interactions between platinum complexes and human serum albumin (HSA) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. Octahedral platinum (IV) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. In this study, the interaction between two Pt(IV) complexes ...